Assay Detail
Functional
CHEMBL5031954
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Antiproliferative activity against human Lovo/DX cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Lovo/DX |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of thiocolchicine amine derivatives and evaluation of their antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.03 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5086702 | — | — | 1 | 8.03 |
| CHEMBL5079219 | — | — | 1 | 7.99 |
| CHEMBL5080050 | — | — | 1 | 7.86 |
| CHEMBL5075235 | — | — | 1 | 7.75 |
| CHEMBL5081186 | — | — | 1 | 7.51 |
| CHEMBL37931 | — | — | 1 | 7.48 |
| CHEMBL5071879 | — | — | 1 | 7.38 |
| CHEMBL5091629 | — | — | 1 | 7.28 |
| CHEMBL1253851 | — | — | 1 | 7.26 |
| CHEMBL5070723 | — | — | 1 | 7.25 |
| CHEMBL5075750 | — | — | 1 | 7.19 |
| CHEMBL5078654 | — | — | 1 | 7.17 |
| CHEMBL5075481 | — | — | 1 | 7.16 |
| CHEMBL5070622 | — | — | 1 | 7.15 |
| CHEMBL5083877 | — | — | 1 | 7.14 |
| CHEMBL5072173 | — | — | 1 | 7.11 |
| CHEMBL298240 | — | — | 1 | 7.11 |
| CHEMBL5072494 | — | — | 1 | 7.07 |
| CHEMBL18981 | THIOCOLCHICINE | — | 1 | 6.80 |
| CHEMBL5087512 | — | — | 1 | 6.68 |
| CHEMBL5076015 | — | — | 1 | 6.63 |
| CHEMBL5089730 | — | — | 1 | 6.40 |
| CHEMBL5086582 | — | — | 1 | 6.16 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 6.01 |
| CHEMBL5092886 | — | — | 1 | 5.70 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5086702 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL5079219 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL5080050 | — | IC50 | = | 13.9 | nM | 7.86 |
| CHEMBL5075235 | — | IC50 | = | 17.9 | nM | 7.75 |
| CHEMBL5081186 | — | IC50 | = | 31.1 | nM | 7.51 |
| CHEMBL37931 | — | IC50 | = | 33.2 | nM | 7.48 |
| CHEMBL5071879 | — | IC50 | = | 41.7 | nM | 7.38 |
| CHEMBL5091629 | — | IC50 | = | 52.3 | nM | 7.28 |
| CHEMBL1253851 | — | IC50 | = | 54.9 | nM | 7.26 |
| CHEMBL5070723 | — | IC50 | = | 56.2 | nM | 7.25 |
| CHEMBL5075750 | — | IC50 | = | 64.9 | nM | 7.19 |
| CHEMBL5078654 | — | IC50 | = | 66.9 | nM | 7.17 |
| CHEMBL5075481 | — | IC50 | = | 69.4 | nM | 7.16 |
| CHEMBL5070622 | — | IC50 | = | 70.2 | nM | 7.15 |
| CHEMBL5083877 | — | IC50 | = | 72.7 | nM | 7.14 |
| CHEMBL5072173 | — | IC50 | = | 77.8 | nM | 7.11 |
| CHEMBL298240 | — | IC50 | = | 77.8 | nM | 7.11 |
| CHEMBL5072494 | — | IC50 | = | 85.6 | nM | 7.07 |
| CHEMBL18981 | THIOCOLCHICINE | IC50 | = | 157.8 | nM | 6.80 |
| CHEMBL5087512 | — | IC50 | = | 210.5 | nM | 6.68 |
| CHEMBL5076015 | — | IC50 | = | 233.9 | nM | 6.63 |
| CHEMBL5089730 | — | IC50 | = | 399.6 | nM | 6.40 |
| CHEMBL5086582 | — | IC50 | = | 692.7 | nM | 6.16 |
| CHEMBL107 | COLCHICINE | IC50 | = | 966.8 | nM | 6.01 |
| CHEMBL5092886 | — | IC50 | = | 1984.1 | nM | 5.70 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 3957.0 | nM | 5.40 |