Assay Detail
ADMET
CHEMBL5031955
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Cytotoxicity against mouse BALB/3T3 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Mus musculus |
| Cell Type | BALB/3T3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of thiocolchicine amine derivatives and evaluation of their antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.34 | 8.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5071879 | — | — | 1 | 8.06 |
| CHEMBL18981 | THIOCOLCHICINE | — | 1 | 8.02 |
| CHEMBL5080050 | — | — | 1 | 8.01 |
| CHEMBL1253851 | — | — | 1 | 7.99 |
| CHEMBL5075481 | — | — | 1 | 7.97 |
| CHEMBL5079219 | — | — | 1 | 7.96 |
| CHEMBL5070723 | — | — | 1 | 7.96 |
| CHEMBL5075235 | — | — | 1 | 7.93 |
| CHEMBL37931 | — | — | 1 | 7.93 |
| CHEMBL5086702 | — | — | 1 | 7.88 |
| CHEMBL5081186 | — | — | 1 | 7.84 |
| CHEMBL298240 | — | — | 1 | 7.81 |
| CHEMBL5089730 | — | — | 1 | 7.30 |
| CHEMBL5078654 | — | — | 1 | 7.21 |
| CHEMBL5070622 | — | — | 1 | 7.11 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.08 |
| CHEMBL5091629 | — | — | 1 | 7.07 |
| CHEMBL5075750 | — | — | 1 | 7.05 |
| CHEMBL5087512 | — | — | 1 | 7.01 |
| CHEMBL5072173 | — | — | 1 | 7.00 |
| CHEMBL5083877 | — | — | 1 | 6.97 |
| CHEMBL5076015 | — | — | 1 | 6.92 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.50 |
| CHEMBL5072494 | — | — | 1 | 6.41 |
| CHEMBL5086582 | — | — | 1 | 5.99 |
| CHEMBL5092886 | — | — | 1 | 5.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5071879 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL18981 | THIOCOLCHICINE | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL5080050 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL1253851 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL5075481 | — | IC50 | = | 10.8 | nM | 7.97 |
| CHEMBL5079219 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5070723 | — | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL5075235 | — | IC50 | = | 11.7 | nM | 7.93 |
| CHEMBL37931 | — | IC50 | = | 11.7 | nM | 7.93 |
| CHEMBL5086702 | — | IC50 | = | 13.3 | nM | 7.88 |
| CHEMBL5081186 | — | IC50 | = | 14.3 | nM | 7.84 |
| CHEMBL298240 | — | IC50 | = | 15.4 | nM | 7.81 |
| CHEMBL5089730 | — | IC50 | = | 50.3 | nM | 7.30 |
| CHEMBL5078654 | — | IC50 | = | 61.2 | nM | 7.21 |
| CHEMBL5070622 | — | IC50 | = | 78.5 | nM | 7.11 |
| CHEMBL107 | COLCHICINE | IC50 | = | 82.3 | nM | 7.08 |
| CHEMBL5091629 | — | IC50 | = | 85.4 | nM | 7.07 |
| CHEMBL5075750 | — | IC50 | = | 88.2 | nM | 7.05 |
| CHEMBL5087512 | — | IC50 | = | 98.6 | nM | 7.01 |
| CHEMBL5072173 | — | IC50 | = | 99.4 | nM | 7.00 |
| CHEMBL5083877 | — | IC50 | = | 106.7 | nM | 6.97 |
| CHEMBL5076015 | — | IC50 | = | 118.9 | nM | 6.92 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 315.0 | nM | 6.50 |
| CHEMBL5072494 | — | IC50 | = | 385.2 | nM | 6.41 |
| CHEMBL5086582 | — | IC50 | = | 1036.3 | nM | 5.99 |
| CHEMBL5092886 | — | IC50 | = | 1068.4 | nM | 5.97 |