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Assay Detail

CHEMBL5032022

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to SARS-CoV-2 spike protein receptor-binding domain by biolayer interferometry (BLI) assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Severe acute respiratory syndrome coronavirus 2
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Spike glycoprotein (CHEMBL4662936)
Type SINGLE PROTEIN
Organism Severe acute respiratory syndrome coronavirus 2

Publication

Computational Design of Potent D-Peptide Inhibitors of SARS-CoV-2.
Valiente PA, Wen H, Nim S, Lee J, Kim HJ, Kim J, Perez-Riba A, Paudel YP, Hwang I, Kim KD, Kim S, Kim PM.
J Med Chem (2021) 64 : 14955 -14967
PubMed 34624194 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 3 7.34 7.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5079992 1 7.54
CHEMBL5085069 1 7.51
CHEMBL5078219 1 6.98

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5079992 Kd = 29.0 nM 7.54
CHEMBL5085069 Kd = 31.0 nM 7.51
CHEMBL5078219 Kd = 105.0 nM 6.98