Assay Detail
Binding
CHEMBL5032054
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Inhibition of castor beans ricin toxin A subunit assessed as depurination of ribosome using yeast ribosomes by qRT-PCR analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ricinus communis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Structural Characterization of Ricin Inhibitors Targeting Ribosome Binding Using Fragment-Based Methods and Structure-Based Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.49 | 4.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5081858 | — | — | 1 | 4.85 |
| CHEMBL5077000 | — | — | 1 | 4.82 |
| CHEMBL1589861 | — | — | 1 | 4.72 |
| CHEMBL5090353 | — | — | 1 | 4.32 |
| CHEMBL3951007 | — | — | 1 | 3.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5081858 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL5077000 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1589861 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL5090353 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL3951007 | — | IC50 | = | 181000.0 | nM | 3.74 |