Assay Detail
Binding
CHEMBL5032409
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human N-terminal His6-tagged KDM4D (M1 to G373 residues) expressed in Escherichia coli using H3K9(Me3) as substrate preincubated for 15 mins followed by substrate addition and measured after 8 mins by Alphascreen assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.55 | 4.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5083418 | — | — | 1 | 4.81 |
| CHEMBL5091848 | — | — | 1 | 4.70 |
| CHEMBL5071515 | — | — | 1 | 4.66 |
| CHEMBL5089880 | — | — | 1 | 4.58 |
| CHEMBL5081435 | — | — | 1 | 4.57 |
| CHEMBL5071002 | — | — | 1 | 4.56 |
| CHEMBL5072902 | — | — | 1 | 4.52 |
| CHEMBL5084638 | — | — | 1 | 4.51 |
| CHEMBL5089117 | — | — | 1 | 4.50 |
| CHEMBL5076580 | — | — | 1 | 4.46 |
| CHEMBL5070745 | — | — | 1 | 4.23 |
| CHEMBL5080728 | — | — | 1 | - |
| CHEMBL5084143 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5083418 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL5091848 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL5071515 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL5089880 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL5081435 | — | IC50 | = | 26700.0 | nM | 4.57 |
| CHEMBL5071002 | — | IC50 | = | 27500.0 | nM | 4.56 |
| CHEMBL5072902 | — | IC50 | = | 30300.0 | nM | 4.52 |
| CHEMBL5084638 | — | IC50 | = | 30800.0 | nM | 4.51 |
| CHEMBL5089117 | — | IC50 | = | 31900.0 | nM | 4.50 |
| CHEMBL5076580 | — | IC50 | = | 34700.0 | nM | 4.46 |
| CHEMBL5070745 | — | IC50 | = | 59100.0 | nM | 4.23 |
| CHEMBL5080728 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5084143 | — | IC50 | = | 123100.0 | nM | - |