Assay Detail
Functional
CHEMBL5032835
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Anti-viral activity against Enterovirus D68 US/MO/14-18949 infected in human RD cells assessed as reduction in virus induced cytopathic effect incubated for 3 days by CPE assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | enterovirus D68 |
| Cell Type | RD |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Potent and Broad-Spectrum Pyrazolopyridine-Containing Antivirals against Enteroviruses D68, A71, and Coxsackievirus B3 by Targeting the Viral 2C Protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.74 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5094626 | — | — | 1 | 7.10 |
| CHEMBL5079166 | — | — | 1 | 7.00 |
| CHEMBL5093400 | — | — | 1 | 6.70 |
| CHEMBL5075415 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5094626 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5079166 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5093400 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5075415 | — | EC50 | = | 700.0 | nM | 6.16 |