Assay Detail
Functional
CHEMBL5032949
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Antiplasmodial activity against asexual blood stage of multidrug-resistant Plasmodium falciparum 7G8 infected in human erythrocytes assessed as reduction in parasite growth incubated for 72 hrs by SYBR green 1 staining based assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Cell Type | Erythrocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Total Synthesis and Antimalarial Activity of 2-(<i>p</i>-Hydroxybenzyl)-prodigiosins, Isoheptylprodigiosin, and Geometric Isomers of Tambjamine MYP1 Isolated from Marine Bacteria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.08 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | 9.70 |
| CHEMBL5078300 | — | — | 1 | 8.68 |
| CHEMBL5080467 | — | — | 1 | 8.44 |
| CHEMBL5073910 | — | — | 1 | 8.39 |
| CHEMBL5093116 | — | — | 1 | 8.25 |
| CHEMBL5090212 | — | — | 1 | 8.06 |
| CHEMBL5077173 | — | — | 1 | 8.04 |
| CHEMBL5083145 | — | — | 1 | 7.89 |
| CHEMBL5082523 | — | — | 1 | 7.80 |
| CHEMBL5092593 | — | — | 1 | 7.57 |
| CHEMBL5076594 | — | — | 1 | 7.36 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1450 | ATOVAQUONE | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5078300 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL5080467 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL5073910 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL5093116 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL5090212 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL5077173 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL5083145 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5082523 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5092593 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5076594 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 171.0 | nM | 6.77 |