Assay Detail
Binding
CHEMBL5033037
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at TAE expressed in human HEK293T cells coexpressing human full-length TLX/Gal4-VP 16 assessed as renilla luciferase reporter activity incubated for 14 hrs by Dual-glo luciferase
7
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nuclear receptor subfamily 2 group E member 1 (CHEMBL1961788) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 4.40 | 4.43 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27 | PROPRANOLOL | 4.0 | 1 | 4.43 |
| CHEMBL31888 | — | — | 1 | 4.37 |
| CHEMBL269236 | TRYPTOLINE | — | 1 | - |
| CHEMBL3304960 | — | — | 1 | - |
| CHEMBL631 | PROPAFENONE | 4.0 | 1 | - |
| CHEMBL24 | ATENOLOL | 4.0 | 1 | - |
| CHEMBL471 | SOTALOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27 | PROPRANOLOL | EC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL31888 | — | EC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL269236 | TRYPTOLINE | EC50 | > | 100000.0 | nM | - |
| CHEMBL3304960 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL631 | PROPAFENONE | EC50 | - | — | - | |
| CHEMBL24 | ATENOLOL | EC50 | - | — | - | |
| CHEMBL471 | SOTALOL | Activity | - | — | - |