Assay Detail
Binding
CHEMBL5033143
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human COX-2 using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 2 mins by EIA
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Activity Evaluation of Stereoconfigured Tartarate Derivatives as Potential Anti-inflammatory Agents <i>In Vitro</i> and <i>In Vivo</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.97 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5089355 | — | — | 1 | 9.00 |
| CHEMBL5077595 | — | — | 1 | 8.40 |
| CHEMBL139 | DICLOFENAC | 4.0 | 1 | 7.70 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 7.40 |
| CHEMBL5079967 | — | — | 1 | 7.00 |
| CHEMBL5085564 | — | — | 1 | 6.64 |
| CHEMBL5089124 | — | — | 1 | 6.40 |
| CHEMBL5084816 | — | — | 1 | 6.30 |
| CHEMBL5083953 | — | — | 1 | 6.27 |
| CHEMBL5075348 | — | — | 1 | 6.16 |
| CHEMBL5082428 | — | — | 1 | 6.16 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 6.02 |
| CHEMBL5075246 | — | — | 1 | 6.00 |
| CHEMBL5085345 | — | — | 1 | 5.82 |
| CHEMBL5080948 | — | — | 1 | 5.55 |
| CHEMBL316040 | TEPOXALIN | 2.0 | 1 | 5.54 |
| CHEMBL5075058 | — | — | 1 | 4.64 |
| CHEMBL5090304 | — | — | 1 | 4.52 |
| CHEMBL5080730 | — | — | 1 | 4.50 |
| CHEMBL5084005 | — | — | 1 | 4.46 |
| CHEMBL5094855 | — | — | 1 | 4.40 |
| CHEMBL5081272 | — | — | 1 | 4.27 |
| CHEMBL5091817 | — | — | 1 | 4.26 |
| CHEMBL300982 | LICOFELONE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5089355 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5077595 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL139 | DICLOFENAC | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL118 | CELECOXIB | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5079967 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5085564 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5089124 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5084816 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5083953 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL5075348 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5082428 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL5075246 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5085345 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5080948 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL316040 | TEPOXALIN | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL5075058 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL5090304 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL5080730 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL5084005 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL5094855 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL5081272 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL5091817 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL300982 | LICOFELONE | IC50 | > | 30000.0 | nM | - |