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Assay Detail

CHEMBL5033583

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Functional
Antiproliferative activity against human U-251 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type U-251
Confidence 1 — Organism
Curated By Autocuration

Target

U-251 (CHEMBL615022)
Type CELL-LINE
Organism Homo sapiens

Publication

N-2-(phenylamino) benzamide derivatives as novel anti-glioblastoma agents: Synthesis and biological evaluation.
Li J, Hu X, Luo T, Lu Y, Feng Y, Zhang H, Liu D, Fan X, Wang Y, Jiang L, Wang Y, Hao X, Shi T, Wang Z.
Eur J Med Chem (2021) 226 : 113817 -113817
PubMed 34537445 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 4.85 6.43

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL84 TOPOTECAN 4.0 1 6.43
CHEMBL5087462 1 5.27
CHEMBL5092199 1 5.00
CHEMBL5090197 1 4.89
CHEMBL5094553 1 4.29
CHEMBL5090568 1 4.06
CHEMBL5079590 1 4.03
CHEMBL5093769 1 -
CHEMBL5085349 1 -
CHEMBL5078291 1 -
CHEMBL5082822 1 -
CHEMBL5076562 1 -
CHEMBL5081898 1 -
CHEMBL5074784 1 -
CHEMBL5088859 1 -
CHEMBL5094539 1 -
CHEMBL5078677 1 -
CHEMBL5080484 1 -
CHEMBL5087242 1 -
CHEMBL5089985 1 -
CHEMBL4172542 1 -
CHEMBL121626 TOLFENAMIC ACID 2.0 1 -
CHEMBL5094564 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL84 TOPOTECAN IC50 = 370.0 nM 6.43
CHEMBL5087462 IC50 = 5360.0 nM 5.27
CHEMBL5092199 IC50 = 9910.0 nM 5.00
CHEMBL5090197 IC50 = 12870.0 nM 4.89
CHEMBL5094553 IC50 = 50730.0 nM 4.29
CHEMBL5090568 IC50 = 86240.0 nM 4.06
CHEMBL5079590 IC50 = 92390.0 nM 4.03
CHEMBL5093769 IC50 > 200000.0 nM -
CHEMBL5085349 IC50 > 200000.0 nM -
CHEMBL5078291 IC50 > 200000.0 nM -
CHEMBL5082822 IC50 = 137580.0 nM -
CHEMBL5076562 IC50 > 200000.0 nM -
CHEMBL5081898 IC50 > 200000.0 nM -
CHEMBL5074784 IC50 = 164630.0 nM -
CHEMBL5088859 IC50 > 200000.0 nM -
CHEMBL5094539 IC50 > 200000.0 nM -
CHEMBL5078677 IC50 = 184460.0 nM -
CHEMBL5080484 IC50 > 200000.0 nM -
CHEMBL5087242 IC50 = 177660.0 nM -
CHEMBL5089985 IC50 > 200000.0 nM -
CHEMBL4172542 IC50 > 200000.0 nM -
CHEMBL121626 TOLFENAMIC ACID IC50 > 100000.0 nM -
CHEMBL5094564 IC50 > 200000.0 nM -