Assay Detail
Binding
CHEMBL5033657
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Inhibition of recombinant human IDO1
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel IDO1 inhibitors targeting the protein's apo form through scaffold hopping from holo-IDO1 inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.05 | 7.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545369 | EPACADOSTAT | 3.0 | 1 | 7.03 |
| CHEMBL5090746 | — | — | 1 | 6.90 |
| CHEMBL5089251 | — | — | 1 | 5.83 |
| CHEMBL5084116 | — | — | 1 | 5.81 |
| CHEMBL5085169 | — | — | 1 | 5.64 |
| CHEMBL5090258 | — | — | 1 | 5.63 |
| CHEMBL5077922 | — | — | 1 | 5.54 |
| CHEMBL5088387 | — | — | 1 | - |
| CHEMBL5079654 | — | — | 1 | - |
| CHEMBL5087424 | — | — | 1 | - |
| CHEMBL5075270 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545369 | EPACADOSTAT | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL5090746 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL5089251 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL5084116 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL5085169 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5090258 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL5077922 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL5088387 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL5079654 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL5087424 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL5075270 | — | IC50 | > | 3000.0 | nM | - |