Assay Detail
Binding
CHEMBL5033658
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Inhibition of IDO1 in human HeLa cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel IDO1 inhibitors targeting the protein's apo form through scaffold hopping from holo-IDO1 inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.18 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4777480 | — | — | 1 | 8.38 |
| CHEMBL5089251 | — | — | 1 | 6.36 |
| CHEMBL5090258 | — | — | 1 | 6.36 |
| CHEMBL5085169 | — | — | 1 | 6.12 |
| CHEMBL5075270 | — | — | 1 | 6.07 |
| CHEMBL5079654 | — | — | 1 | 5.87 |
| CHEMBL5084116 | — | — | 1 | 5.87 |
| CHEMBL5087424 | — | — | 1 | 5.68 |
| CHEMBL5077922 | — | — | 1 | 5.58 |
| CHEMBL5088387 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4777480 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL5089251 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL5090258 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL5085169 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL5075270 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL5079654 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL5084116 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL5087424 | — | IC50 | = | 2090.0 | nM | 5.68 |
| CHEMBL5077922 | — | IC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL5088387 | — | IC50 | = | 3110.0 | nM | 5.51 |