Assay Detail
Binding
CHEMBL5033899
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of p300 (unknown origin) preincubated for 15 mins followed by addition of substrate [3H] Ac-CoA and measured after 60 mins by liquid scintillation counting assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of a novel spiro oxazolidinedione as potent p300/CBP HAT inhibitor for the treatment of ovarian cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 8.26 | 9.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5090239 | — | — | 1 | 9.31 |
| CHEMBL5082755 | — | — | 1 | 9.25 |
| CHEMBL4475351 | — | — | 1 | 9.02 |
| CHEMBL5083020 | — | — | 1 | 8.77 |
| CHEMBL5077158 | — | — | 1 | 8.66 |
| CHEMBL4524352 | — | — | 1 | 8.60 |
| CHEMBL5094423 | — | — | 1 | 8.40 |
| CHEMBL5081689 | — | — | 1 | 8.07 |
| CHEMBL5078353 | — | — | 1 | 8.07 |
| CHEMBL5078021 | — | — | 1 | 8.01 |
| CHEMBL5085891 | — | — | 1 | 8.00 |
| CHEMBL5083262 | — | — | 1 | 7.96 |
| CHEMBL5073432 | — | — | 1 | 7.92 |
| CHEMBL5084035 | — | — | 1 | 7.89 |
| CHEMBL4282264 | A-485 | — | 1 | 7.82 |
| CHEMBL5089370 | — | — | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5090239 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL5082755 | — | IC50 | = | 0.56 | nM | 9.25 |
| CHEMBL4475351 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL5083020 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL5077158 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4524352 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL5094423 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5081689 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL5078353 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL5078021 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL5085891 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5083262 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5073432 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5084035 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4282264 | A-485 | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5089370 | — | IC50 | = | 430.0 | nM | 6.37 |