Assay Detail
Functional
CHEMBL5033944
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Antiproliferative activity against human M21 cells assessed as inhibition of cell proliferation measured after 48 hrs by SRB assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | M21 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthetic development of sugar amino acid oligomers towards novel podophyllotoxin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.10 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.72 |
| CHEMBL31929 | 4'-DEMETHYLEPIPODOPHYLLOTOXIN | — | 1 | 6.77 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.70 |
| CHEMBL310810 | — | — | 1 | 6.22 |
| CHEMBL5091369 | — | — | 1 | - |
| CHEMBL5086889 | — | — | 1 | - |
| CHEMBL5093842 | — | — | 1 | - |
| CHEMBL5077890 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL31929 | 4'-DEMETHYLEPIPODOPHYLLOTOXIN | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL310810 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL5091369 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5086889 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5093842 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5077890 | — | IC50 | > | 100000.0 | nM | - |