Assay Detail
Binding
CHEMBL5034078
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Binding affinity to Staphylococcus aureus FtsZ polymer assessed as dissociation constant by fluorescence anisotropy analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Targeting the FtsZ Allosteric Binding Site with a Novel Fluorescence Polarization Screen, Cytological and Structural Approaches for Antibacterial Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 5.95 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5076150 | — | — | 1 | 6.52 |
| CHEMBL5080731 | — | — | 1 | 6.16 |
| CHEMBL5089927 | — | — | 1 | 5.16 |
| CHEMBL5085404 | — | — | 1 | - |
| CHEMBL511201 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5076150 | — | Kd | = | 300.0 | nM | 6.52 |
| CHEMBL5080731 | — | Kd | = | 700.0 | nM | 6.16 |
| CHEMBL5089927 | — | Kd | = | 7000.0 | nM | 5.16 |
| CHEMBL5085404 | — | Kd | < | 100.0 | nM | - |
| CHEMBL511201 | — | Kd | < | 100.0 | nM | - |