Assay Detail
Functional
CHEMBL5034201
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In vivo inhibition of BACE1 in dog assessed as reduction in amyloid-beta level at 3 mg/kg, po measured upto 48 hrs by sandwich ELISA assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canis lupus familiaris |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.85 | 10.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4452566 | — | — | 1 | 10.01 |
| CHEMBL3667410 | — | — | 1 | 9.92 |
| CHEMBL3667415 | — | — | 1 | 9.89 |
| CHEMBL2396989 | LY-2886721 | 1.0 | 1 | 7.85 |
| CHEMBL3701713 | — | — | 1 | 6.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4452566 | — | IC50 | = | 0.097 | nM | 10.01 |
| CHEMBL3667410 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL3667415 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL2396989 | LY-2886721 | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3701713 | — | IC50 | = | 276.0 | nM | 6.56 |