Assay Detail
Functional
CHEMBL5034224
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Bioactivity Evaluation of Dual-Target Inhibitors of Tubulin and Src Kinase Guided by Crystal Structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.81 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5088088 | — | — | 1 | 9.00 |
| CHEMBL5093827 | — | — | 1 | 8.85 |
| CHEMBL5090833 | — | — | 1 | 8.64 |
| CHEMBL5082965 | — | — | 1 | 8.60 |
| CHEMBL5077255 | — | — | 1 | 8.24 |
| CHEMBL5085447 | — | — | 1 | 8.21 |
| CHEMBL5076501 | — | — | 1 | 7.89 |
| CHEMBL5081672 | — | — | 1 | 7.84 |
| CHEMBL5090203 | — | — | 1 | 7.84 |
| CHEMBL5080137 | — | — | 1 | 7.79 |
| CHEMBL5077747 | — | — | 1 | 7.78 |
| CHEMBL571546 | TIRBANIBULIN | 4.0 | 1 | 7.74 |
| CHEMBL5074662 | — | — | 1 | 7.54 |
| CHEMBL5075500 | — | — | 1 | 7.53 |
| CHEMBL5087651 | — | — | 1 | 7.53 |
| CHEMBL5081690 | — | — | 1 | 7.53 |
| CHEMBL5086952 | — | — | 1 | 7.47 |
| CHEMBL5075061 | — | — | 1 | 7.42 |
| CHEMBL5079383 | — | — | 1 | 7.40 |
| CHEMBL5074616 | — | — | 1 | 7.39 |
| CHEMBL5081745 | — | — | 1 | 7.38 |
| CHEMBL5082859 | — | — | 1 | 7.29 |
| CHEMBL5082820 | — | — | 1 | 7.27 |
| CHEMBL5092338 | — | — | 1 | 7.27 |
| CHEMBL5074452 | — | — | 1 | - |
| CHEMBL5082538 | — | — | 1 | - |
| CHEMBL5076856 | — | — | 1 | - |
| CHEMBL5079879 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5088088 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5093827 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5090833 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL5082965 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL5077255 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL5085447 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL5076501 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5081672 | — | IC50 | = | 14.6 | nM | 7.84 |
| CHEMBL5090203 | — | IC50 | = | 14.4 | nM | 7.84 |
| CHEMBL5080137 | — | IC50 | = | 16.2 | nM | 7.79 |
| CHEMBL5077747 | — | IC50 | = | 16.5 | nM | 7.78 |
| CHEMBL571546 | TIRBANIBULIN | IC50 | = | 18.2 | nM | 7.74 |
| CHEMBL5074662 | — | IC50 | = | 29.2 | nM | 7.54 |
| CHEMBL5075500 | — | IC50 | = | 29.6 | nM | 7.53 |
| CHEMBL5087651 | — | IC50 | = | 29.3 | nM | 7.53 |
| CHEMBL5081690 | — | IC50 | = | 29.4 | nM | 7.53 |
| CHEMBL5086952 | — | IC50 | = | 34.1 | nM | 7.47 |
| CHEMBL5075061 | — | IC50 | = | 37.9 | nM | 7.42 |
| CHEMBL5079383 | — | IC50 | = | 39.9 | nM | 7.40 |
| CHEMBL5074616 | — | IC50 | = | 40.5 | nM | 7.39 |
| CHEMBL5081745 | — | IC50 | = | 41.5 | nM | 7.38 |
| CHEMBL5082859 | — | IC50 | = | 50.9 | nM | 7.29 |
| CHEMBL5082820 | — | IC50 | = | 53.2 | nM | 7.27 |
| CHEMBL5092338 | — | IC50 | = | 53.5 | nM | 7.27 |
| CHEMBL5074452 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5082538 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5076856 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5079879 | — | IC50 | > | 100.0 | nM | - |