Assay Detail
Binding
CHEMBL5034734
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Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by fluoresence-based assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Second-Generation Dual FXR/sEH Modulators with Optimized Pharmacokinetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.64 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5089068 | — | — | 1 | 8.70 |
| CHEMBL5086882 | — | — | 1 | 8.40 |
| CHEMBL4066332 | — | — | 1 | 8.39 |
| CHEMBL5092609 | — | — | 1 | 8.37 |
| CHEMBL5092029 | — | — | 1 | 8.21 |
| CHEMBL5093975 | — | — | 1 | 8.15 |
| CHEMBL5081303 | — | — | 1 | 8.11 |
| CHEMBL5094442 | — | — | 1 | 8.05 |
| CHEMBL5083711 | — | — | 1 | 8.00 |
| CHEMBL5080537 | — | — | 1 | 7.95 |
| CHEMBL5073088 | — | — | 1 | 7.92 |
| CHEMBL5087098 | — | — | 1 | 7.89 |
| CHEMBL5090511 | — | — | 1 | 7.80 |
| CHEMBL5081384 | — | — | 1 | 7.68 |
| CHEMBL5071639 | — | — | 1 | 7.66 |
| CHEMBL5075316 | — | — | 1 | 7.51 |
| CHEMBL5070912 | — | — | 1 | 7.42 |
| CHEMBL4095371 | — | — | 1 | 7.40 |
| CHEMBL5093488 | — | — | 1 | 7.39 |
| CHEMBL5075589 | — | — | 1 | 7.35 |
| CHEMBL5082993 | — | — | 1 | 7.31 |
| CHEMBL5083732 | — | — | 1 | 7.15 |
| CHEMBL5085799 | — | — | 1 | 7.07 |
| CHEMBL5074951 | — | — | 1 | 7.03 |
| CHEMBL5091524 | — | — | 1 | 6.96 |
| CHEMBL5079511 | — | — | 1 | 6.77 |
| CHEMBL5090857 | — | — | 1 | 6.76 |
| CHEMBL5071516 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5089068 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5086882 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4066332 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL5092609 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL5092029 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL5093975 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5081303 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL5094442 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5083711 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5080537 | — | IC50 | = | 11.2 | nM | 7.95 |
| CHEMBL5073088 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5087098 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5090511 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5081384 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5071639 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5075316 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL5070912 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4095371 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5093488 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL5075589 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL5082993 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL5083732 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL5085799 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL5074951 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL5091524 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL5079511 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5090857 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL5071516 | — | IC50 | = | 268.0 | nM | 6.57 |