Assay Detail
Binding
CHEMBL5034778
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Inhibition of Escherichia coli beta-lactamase NDM-1 using nitrocefin chromogenic substrate measured after 15 to 60 min at 25 degC by microplate reader
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel Cephalosporin Conjugates Display Potent and Selective Inhibition of Imipenemase-Type Metallo-β-Lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.20 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284104 | DIPICOLINIC ACID | — | 1 | 5.00 |
| CHEMBL5083116 | — | — | 1 | 4.29 |
| CHEMBL5086713 | — | — | 1 | 4.14 |
| CHEMBL5082828 | — | — | 1 | 4.11 |
| CHEMBL5086599 | — | — | 1 | 4.03 |
| CHEMBL5076350 | — | — | 1 | 4.00 |
| CHEMBL5074200 | — | — | 1 | 4.00 |
| CHEMBL115860 | — | — | 1 | 4.00 |
| CHEMBL5076493 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284104 | DIPICOLINIC ACID | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5083116 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL5086713 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL5082828 | — | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL5086599 | — | IC50 | = | 94000.0 | nM | 4.03 |
| CHEMBL5076350 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL5074200 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL115860 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL5076493 | — | IC50 | > | 100000.0 | nM | - |