Assay Detail
Functional
CHEMBL5034989
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
87
Total Activities
87
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Based Optimization of 3-Phenyl-<i>N</i>-(2-(3-phenylureido)ethyl)thiophene-2-sulfonamide Derivatives as Selective Mcl-1 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 87 | 5.02 | 5.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5075238 | — | — | 1 | 5.34 |
| CHEMBL5078061 | — | — | 1 | 5.33 |
| CHEMBL5088778 | — | — | 1 | 5.27 |
| CHEMBL5088326 | — | — | 1 | 5.19 |
| CHEMBL5088505 | — | — | 1 | 5.19 |
| CHEMBL5092026 | — | — | 1 | 5.17 |
| CHEMBL5086158 | — | — | 1 | 5.16 |
| CHEMBL5086774 | — | — | 1 | 5.15 |
| CHEMBL5091077 | — | — | 1 | 5.10 |
| CHEMBL5086470 | — | — | 1 | 5.08 |
| CHEMBL5086162 | — | — | 1 | 5.08 |
| CHEMBL5077322 | — | — | 1 | 5.01 |
| CHEMBL5086607 | — | — | 1 | 5.00 |
| CHEMBL5086959 | — | — | 1 | 4.99 |
| CHEMBL5089059 | — | — | 1 | 4.98 |
| CHEMBL5094114 | — | — | 1 | 4.97 |
| CHEMBL5085546 | — | — | 1 | 4.96 |
| CHEMBL5093686 | — | — | 1 | 4.96 |
| CHEMBL5086500 | — | — | 1 | 4.94 |
| CHEMBL5080557 | — | — | 1 | 4.94 |
| CHEMBL5083884 | — | — | 1 | 4.92 |
| CHEMBL5085725 | — | — | 1 | 4.92 |
| CHEMBL5085668 | — | — | 1 | 4.89 |
| CHEMBL5076305 | — | — | 1 | 4.87 |
| CHEMBL5083775 | — | — | 1 | 4.85 |
| CHEMBL5085875 | — | — | 1 | 4.83 |
| CHEMBL5089773 | — | — | 1 | 4.83 |
| CHEMBL5070694 | — | — | 1 | 4.76 |
| CHEMBL5072573 | — | — | 1 | - |
| CHEMBL5072266 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5075238 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL5078061 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL5088778 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL5088326 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL5088505 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL5092026 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL5086158 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL5086774 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL5091077 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL5086470 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL5086162 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL5077322 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL5086607 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL5086959 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL5089059 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL5094114 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL5085546 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL5093686 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL5086500 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL5080557 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL5083884 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL5085725 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL5085668 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL5076305 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL5083775 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL5085875 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL5089773 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL5070694 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL5083526 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5076521 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5094788 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5075097 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5089860 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5083087 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5090548 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5077284 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5085307 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5084712 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5084852 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5073247 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5092285 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5078646 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3137309 | VENETOCLAX | IC50 | > | 20000.0 | nM | - |
| CHEMBL3417704 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5091237 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5081541 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5080935 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5083051 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5072266 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5072573 | — | IC50 | > | 50000.0 | nM | - |