Assay Detail
ADMET
CHEMBL5034993
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Cytotoxicity against HEK293T cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
86
Total Activities
86
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Based Optimization of 3-Phenyl-<i>N</i>-(2-(3-phenylureido)ethyl)thiophene-2-sulfonamide Derivatives as Selective Mcl-1 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 86 | 4.96 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5075238 | — | — | 1 | 5.30 |
| CHEMBL5086607 | — | — | 1 | 5.22 |
| CHEMBL5088326 | — | — | 1 | 5.17 |
| CHEMBL5088505 | — | — | 1 | 5.17 |
| CHEMBL5080935 | — | — | 1 | 5.17 |
| CHEMBL5076953 | — | — | 1 | 5.12 |
| CHEMBL5084152 | — | — | 1 | 5.10 |
| CHEMBL5091077 | — | — | 1 | 5.10 |
| CHEMBL5092026 | — | — | 1 | 5.09 |
| CHEMBL5090332 | — | — | 1 | 5.07 |
| CHEMBL5078061 | — | — | 1 | 5.07 |
| CHEMBL5086959 | — | — | 1 | 5.05 |
| CHEMBL5089059 | — | — | 1 | 5.05 |
| CHEMBL5086774 | — | — | 1 | 5.05 |
| CHEMBL5090868 | — | — | 1 | 5.05 |
| CHEMBL5086470 | — | — | 1 | 4.99 |
| CHEMBL5086162 | — | — | 1 | 4.99 |
| CHEMBL5088778 | — | — | 1 | 4.98 |
| CHEMBL5089281 | — | — | 1 | 4.97 |
| CHEMBL5085725 | — | — | 1 | 4.94 |
| CHEMBL5080557 | — | — | 1 | 4.92 |
| CHEMBL5086158 | — | — | 1 | 4.92 |
| CHEMBL5086500 | — | — | 1 | 4.92 |
| CHEMBL5091070 | — | — | 1 | 4.91 |
| CHEMBL5079843 | — | — | 1 | 4.91 |
| CHEMBL5075430 | — | — | 1 | 4.88 |
| CHEMBL5093686 | — | — | 1 | 4.86 |
| CHEMBL5083775 | — | — | 1 | 4.85 |
| CHEMBL5089773 | — | — | 1 | 4.81 |
| CHEMBL5083051 | — | — | 1 | 4.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5075238 | — | IC50 | = | 4990.0 | nM | 5.30 |
| CHEMBL5086607 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL5088505 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL5080935 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL5088326 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL5076953 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL5084152 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL5091077 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL5092026 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL5090332 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL5078061 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL5090868 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL5086774 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL5089059 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL5086959 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL5086470 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL5086162 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL5088778 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL5089281 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL5085725 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL5080557 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL5086158 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL5086500 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL5091070 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL5079843 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL5075430 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL5093686 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL5083775 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL5089773 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL5083051 | — | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL5084869 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL5079372 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL5094114 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL5086831 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL5092439 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL5085668 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL5076103 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL5085660 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5075097 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5075181 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5080460 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5092837 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5089455 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5081541 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5084489 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5080646 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5083526 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5076521 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5094788 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5091453 | — | IC50 | > | 20000.0 | nM | - |