Assay Detail
Binding
CHEMBL5035183
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Inhibition of TrKC (unknown origin) incubated for 120 mins in presence of 33P-ATP
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of the Next-Generation Pan-TRK Kinase Inhibitors for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 9.88 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4298138 | REPOTRECTINIB | 4.0 | 1 | 11.00 |
| CHEMBL5093999 | — | — | 1 | 9.70 |
| CHEMBL5070835 | — | — | 1 | 9.70 |
| CHEMBL5080010 | — | — | 1 | 9.70 |
| CHEMBL4297627 | SELITRECTINIB | 2.0 | 1 | 9.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4298138 | REPOTRECTINIB | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL5093999 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5070835 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5080010 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4297627 | SELITRECTINIB | IC50 | = | 0.5 | nM | 9.30 |