Assay Detail
Binding
CHEMBL5035185
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ROS1 (unknown origin) incubated for 120 mins in presence of 33P-ATP
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Proto-oncogene tyrosine-protein kinase ROS (CHEMBL5568) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of the Next-Generation Pan-TRK Kinase Inhibitors for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 9.27 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4298138 | REPOTRECTINIB | 4.0 | 1 | 9.77 |
| CHEMBL5093999 | — | — | 1 | 9.70 |
| CHEMBL5080010 | — | — | 1 | 9.00 |
| CHEMBL4297627 | SELITRECTINIB | 2.0 | 1 | 8.94 |
| CHEMBL5070835 | — | — | 1 | 8.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4298138 | REPOTRECTINIB | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL5093999 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5080010 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4297627 | SELITRECTINIB | IC50 | = | 1.15 | nM | 8.94 |
| CHEMBL5070835 | — | IC50 | = | 1.2 | nM | 8.92 |