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Assay Detail

CHEMBL5035329

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human Calpain-1 incubated for 60 mins by Bio-Rad protein assay dye reagent based assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Calpain-1 catalytic subunit (CHEMBL3891)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Self-Masked Aldehyde Inhibitors: A Novel Strategy for Inhibiting Cysteine Proteases.
Li L, Chenna BC, Yang KS, Cole TR, Goodall ZT, Giardini M, Moghadamchargari Z, Hernandez EA, Gomez J, Calvet CM, Bernatchez JA, Mellott DM, Zhu J, Rademacher A, Thomas D, Blankenship LR, Drelich A, Laganowsky A, Tseng CK, Liu WR, Wand AJ, Cruz-Reyes J, Siqueira-Neto JL, Meek TD.
J Med Chem (2021) 64 : 11267 -11287
PubMed 34288674 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 7.66 7.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL288365 1 7.66

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL288365 IC50 = 22.0 nM 7.66