Assay Detail

CHEMBL5035490

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Binding

Inhibition of PDE4 (unknown origin) by Fluopol-ABPP HTS assay

ChEMBL ↗

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Target

Phosphodiesterase 4 (CHEMBL2093863) ↗

Open DB target context

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Phosphodiesterase 4 (CHEMBL2093863) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Phosphodiesterase 4

CHEMBL2093863

Anchored from Assay target.

Protein identity Phosphodiesterase 4

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	5 — Multiple protein complex / RNA
Curated By	Autocuration

Target

Phosphodiesterase 4 (CHEMBL2093863) ↗

Type	PROTEIN FAMILY
Organism	Homo sapiens

Publication

Peptidylarginine deiminases 4 as a promising target in drug discovery.

Yang C, Dong ZZ, Zhang J, Teng D, Luo X, Li D, Zhou Y.
Eur J Med Chem (2021) 226 : 113840 -113840
PubMed 34520958 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.18	6.62

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL58150	—	—	1	6.62
CHEMBL11417	STREPTONIGRIN	2.0	1	5.73

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL58150	—	IC50	=	240.0	nM	6.62
CHEMBL11417	STREPTONIGRIN	IC50	=	1870.0	nM	5.73