Assay Detail
Binding
CHEMBL5035545
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reversal of Pgp-mediated paclitaxel resistance in human LCC6MDR cells assessed as paclitaxel IC50 at 1 uM after 5 days by Cell Titer-Glo luminescence assay (Rvb = 152.5 +/- 9.7 uM)
54
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | LCC6MDR |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of stereoisomers of methylated catechin and epigallocatechin derivatives on modulating P-glycoprotein-mediated multidrug resistance in cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 54 | 7.83 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5089855 | — | — | 1 | 8.74 |
| CHEMBL5088809 | — | — | 1 | 8.66 |
| CHEMBL5087858 | — | — | 1 | 8.59 |
| CHEMBL5077283 | — | — | 1 | 8.57 |
| CHEMBL5093699 | — | — | 1 | 8.57 |
| CHEMBL3582168 | — | — | 1 | 8.57 |
| CHEMBL3582155 | — | — | 1 | 8.52 |
| CHEMBL3582156 | — | — | 1 | 8.48 |
| CHEMBL3582149 | — | — | 1 | 8.43 |
| CHEMBL5088447 | — | — | 1 | 8.40 |
| CHEMBL5070356 | — | — | 1 | 8.39 |
| CHEMBL3582170 | — | — | 1 | 8.38 |
| CHEMBL3582167 | — | — | 1 | 8.34 |
| CHEMBL5085351 | — | — | 1 | 8.33 |
| CHEMBL5070982 | — | — | 1 | 8.29 |
| CHEMBL5078535 | — | — | 1 | 8.28 |
| CHEMBL3582154 | — | — | 1 | 8.21 |
| CHEMBL5070920 | — | — | 1 | 8.18 |
| CHEMBL5089764 | — | — | 1 | 8.08 |
| CHEMBL5076962 | — | — | 1 | 8.01 |
| CHEMBL5075396 | — | — | 1 | 7.99 |
| CHEMBL5089629 | — | — | 1 | 7.97 |
| CHEMBL5084862 | — | — | 1 | 7.94 |
| CHEMBL3582166 | — | — | 1 | 7.94 |
| CHEMBL5078710 | — | — | 1 | 7.92 |
| CHEMBL5070322 | — | — | 1 | 7.92 |
| CHEMBL5077165 | — | — | 1 | 7.92 |
| CHEMBL5081485 | — | — | 1 | 7.90 |
| CHEMBL5083784 | — | — | 1 | 7.85 |
| CHEMBL5090495 | — | — | 1 | 7.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5089855 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL5088809 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL5087858 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL5077283 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL5093699 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3582168 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3582155 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3582156 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL3582149 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL5088447 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5070356 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL3582170 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL3582167 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL5085351 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL5070982 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL5078535 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL3582154 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL5070920 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL5089764 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL5076962 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL5075396 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL5089629 | — | IC50 | = | 10.6 | nM | 7.97 |
| CHEMBL5084862 | — | IC50 | = | 11.5 | nM | 7.94 |
| CHEMBL3582166 | — | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL5077165 | — | IC50 | = | 11.9 | nM | 7.92 |
| CHEMBL5070322 | — | IC50 | = | 11.9 | nM | 7.92 |
| CHEMBL5078710 | — | IC50 | = | 12.1 | nM | 7.92 |
| CHEMBL5081485 | — | IC50 | = | 12.5 | nM | 7.90 |
| CHEMBL5083784 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5090495 | — | IC50 | = | 14.8 | nM | 7.83 |
| CHEMBL5075802 | — | IC50 | = | 14.8 | nM | 7.83 |
| CHEMBL5075658 | — | IC50 | = | 15.2 | nM | 7.82 |
| CHEMBL5085994 | — | IC50 | = | 16.6 | nM | 7.78 |
| CHEMBL5092634 | — | IC50 | = | 16.8 | nM | 7.78 |
| CHEMBL5074075 | — | IC50 | = | 17.1 | nM | 7.77 |
| CHEMBL5083408 | — | IC50 | = | 18.6 | nM | 7.73 |
| CHEMBL1631996 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5082262 | — | IC50 | = | 22.9 | nM | 7.64 |
| CHEMBL5090248 | — | IC50 | = | 24.7 | nM | 7.61 |
| CHEMBL5080462 | — | IC50 | = | 36.9 | nM | 7.43 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL5082589 | — | IC50 | = | 44.7 | nM | 7.35 |
| CHEMBL5093877 | — | IC50 | = | 49.1 | nM | 7.31 |
| CHEMBL3582163 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL5092682 | — | IC50 | = | 93.7 | nM | 7.03 |
| CHEMBL5072407 | — | IC50 | = | 107.7 | nM | 6.97 |
| CHEMBL5083857 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL3039226 | CATECHIN TETRAMETHYLETHER | IC50 | = | 117.5 | nM | 6.93 |
| CHEMBL5074687 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | IC50 | = | 124.1 | nM | 6.91 |