Assay Detail
Binding
CHEMBL5035548
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reversal of P-glycoprotein mediated drug resistance in human LCC6MDR cells assessed as reversal of paclitaxel resistance measured after 5 days by Cell Titer-Glo luminescence assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | LCC6MDR |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of stereoisomers of methylated catechin and epigallocatechin derivatives on modulating P-glycoprotein-mediated multidrug resistance in cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 6.86 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 7.50 |
| CHEMBL5089855 | — | — | 1 | 7.05 |
| CHEMBL5088809 | — | — | 1 | 7.03 |
| CHEMBL5093699 | — | — | 1 | 6.87 |
| CHEMBL3582168 | — | — | 1 | 6.85 |
| CHEMBL3582155 | — | — | 1 | 6.80 |
| CHEMBL3582167 | — | — | 1 | 6.77 |
| CHEMBL5087858 | — | — | 1 | 6.75 |
| CHEMBL3582156 | — | — | 1 | 6.67 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 6.35 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5089855 | — | EC50 | = | 89.9 | nM | 7.05 |
| CHEMBL5088809 | — | EC50 | = | 92.8 | nM | 7.03 |
| CHEMBL5093699 | — | EC50 | = | 135.0 | nM | 6.87 |
| CHEMBL3582168 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3582155 | — | EC50 | = | 159.0 | nM | 6.80 |
| CHEMBL3582167 | — | EC50 | = | 171.0 | nM | 6.77 |
| CHEMBL5087858 | — | EC50 | = | 177.5 | nM | 6.75 |
| CHEMBL3582156 | — | EC50 | = | 214.0 | nM | 6.67 |
| CHEMBL6966 | VERAPAMIL | EC50 | = | 445.7 | nM | 6.35 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | EC50 | > | 1000.0 | nM | - |