Assay Detail
Binding
CHEMBL5035549
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reversal of P-glycoprotein mediated drug resistance in human LCC6MDR cells assessed as reversal of Dox resistance measured after 5 days by Cell Titer-Glo luminescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | LCC6MDR |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of stereoisomers of methylated catechin and epigallocatechin derivatives on modulating P-glycoprotein-mediated multidrug resistance in cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.17 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5089855 | — | — | 1 | 7.50 |
| CHEMBL5088809 | — | — | 1 | 7.43 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5089855 | — | EC50 | = | 31.8 | nM | 7.50 |
| CHEMBL5088809 | — | EC50 | = | 37.3 | nM | 7.43 |
| CHEMBL6966 | VERAPAMIL | EC50 | = | 254.4 | nM | 6.59 |