Assay Detail
Binding
CHEMBL5035554
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of P-glycoprotein in human LCC6MDR cells assessed as reversal fold by measuring reduction in paclitaxel by measuring paclitaxel IC50 at 1 uM after 5 days by Cell Titer-Glo luminescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | LCC6MDR |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of stereoisomers of methylated catechin and epigallocatechin derivatives on modulating P-glycoprotein-mediated multidrug resistance in cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.27 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5089855 | — | — | 1 | 8.74 |
| CHEMBL5088809 | — | — | 1 | 8.66 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5089855 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL5088809 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 38.0 | nM | 7.42 |