Assay Detail
Binding
CHEMBL5036112
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Influenza A virus (A/Moscow/10/99(H3N2)) neuraminidase N2 using MUNANA as substrate preincubated for 30 mins followed by substrate addition by fluorescence method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Zanamivir-Cholesterol Conjugate: A Long-Acting Neuraminidase Inhibitor with Potent Efficacy against Drug-Resistant Influenza Viruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.80 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 9.30 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 9.15 |
| CHEMBL5093304 | — | — | 1 | 7.79 |
| CHEMBL5084242 | — | — | 1 | 7.54 |
| CHEMBL5093840 | — | — | 1 | 6.93 |
| CHEMBL5080451 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL5093304 | — | IC50 | = | 16.1 | nM | 7.79 |
| CHEMBL5084242 | — | IC50 | = | 29.1 | nM | 7.54 |
| CHEMBL5093840 | — | IC50 | = | 117.2 | nM | 6.93 |
| CHEMBL5080451 | — | IC50 | = | 861.2 | nM | 6.07 |