Assay Detail
Binding
CHEMBL5036115
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Inhibition of Influenza A virus (A/Moscow/10/99 (H3N2)) neuraminidase N2 E119V variant using MUNANA as substrate preincubated for 30 mins followed by substrate addition by fluorescence method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Zanamivir-Cholesterol Conjugate: A Long-Acting Neuraminidase Inhibitor with Potent Efficacy against Drug-Resistant Influenza Viruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.69 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 8.00 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 7.65 |
| CHEMBL5093304 | — | — | 1 | 6.79 |
| CHEMBL5084242 | — | — | 1 | 6.53 |
| CHEMBL5093840 | — | — | 1 | 6.11 |
| CHEMBL5080451 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 22.4 | nM | 7.65 |
| CHEMBL5093304 | — | IC50 | = | 162.4 | nM | 6.79 |
| CHEMBL5084242 | — | IC50 | = | 296.0 | nM | 6.53 |
| CHEMBL5093840 | — | IC50 | = | 773.3 | nM | 6.11 |
| CHEMBL5080451 | — | IC50 | = | 8582.3 | nM | 5.07 |