Assay Detail
Functional
CHEMBL5036175
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Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability incubated for 24 hrs by Celltiter-Glo cell viability assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Amide-to-Ester Substitution as a Strategy for Optimizing PROTAC Permeability and Cellular Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.20 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5087181 | — | — | 1 | 8.40 |
| CHEMBL4215078 | — | — | 1 | 7.70 |
| CHEMBL5079045 | — | — | 1 | 7.30 |
| CHEMBL5075400 | — | — | 1 | 7.00 |
| CHEMBL5086339 | — | — | 1 | 6.90 |
| CHEMBL4226570 | — | — | 1 | 6.90 |
| CHEMBL5081695 | — | — | 1 | 6.70 |
| CHEMBL5074720 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5087181 | — | EC50 | = | 3.981 | nM | 8.40 |
| CHEMBL4215078 | — | EC50 | = | 19.95 | nM | 7.70 |
| CHEMBL5079045 | — | EC50 | = | 50.12 | nM | 7.30 |
| CHEMBL5075400 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5086339 | — | EC50 | = | 125.89 | nM | 6.90 |
| CHEMBL4226570 | — | EC50 | = | 125.89 | nM | 6.90 |
| CHEMBL5081695 | — | EC50 | = | 199.53 | nM | 6.70 |
| CHEMBL5074720 | — | EC50 | = | 199.53 | nM | 6.70 |