Assay Detail
Functional
CHEMBL5036176
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Antiproliferative activity against human 22Rv1 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo cell viability assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CWR22R |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Amide-to-Ester Substitution as a Strategy for Optimizing PROTAC Permeability and Cellular Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.58 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4215078 | — | — | 1 | 7.36 |
| CHEMBL5087181 | — | — | 1 | 7.20 |
| CHEMBL5079045 | — | — | 1 | 6.60 |
| CHEMBL5086339 | — | — | 1 | 6.50 |
| CHEMBL5075400 | — | — | 1 | 6.40 |
| CHEMBL4226570 | — | — | 1 | 6.30 |
| CHEMBL5074720 | — | — | 1 | 6.20 |
| CHEMBL5081695 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4215078 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL5087181 | — | EC50 | = | 63.1 | nM | 7.20 |
| CHEMBL5079045 | — | EC50 | = | 251.19 | nM | 6.60 |
| CHEMBL5086339 | — | EC50 | = | 316.23 | nM | 6.50 |
| CHEMBL5075400 | — | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL4226570 | — | EC50 | = | 501.19 | nM | 6.30 |
| CHEMBL5074720 | — | EC50 | = | 630.96 | nM | 6.20 |
| CHEMBL5081695 | — | EC50 | = | 794.33 | nM | 6.10 |