Assay Detail
Binding
CHEMBL5036221
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Inhibition of human PAD4 using BAEE as substrate incubated for 30 mins by spectrophotometric based assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Macrocyclic Peptidylarginine Deiminase Type 4 (PAD4) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.27 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5070220 | — | — | 1 | 8.30 |
| CHEMBL5083901 | — | — | 1 | 8.30 |
| CHEMBL5070080 | — | — | 1 | 8.30 |
| CHEMBL5087104 | — | — | 1 | 8.30 |
| CHEMBL5093574 | — | — | 1 | 8.22 |
| CHEMBL5080973 | — | — | 1 | 8.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5070220 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5083901 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5070080 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5087104 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5093574 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5080973 | — | IC50 | = | 6.0 | nM | 8.22 |