Assay Detail
Functional
CHEMBL5036387
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against Leishmania infantum MHOM/MA(BE)/67 amastigotes infected in macrophages assessed as reduction in parasite burden by giemsa staining based microscopic analysis
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania infantum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Heteroaryl ether analogues of an antileishmanial 7-substituted 2-nitroimidazooxazine lead afford attenuated hERG risk: In vitro and in vivo appraisal.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 6.32 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4094088 | — | — | 1 | 7.33 |
| CHEMBL5073339 | — | — | 1 | 7.01 |
| CHEMBL4740928 | — | — | 1 | 6.89 |
| CHEMBL4066553 | — | — | 1 | 6.89 |
| CHEMBL5085151 | — | — | 1 | 6.80 |
| CHEMBL5077758 | — | — | 1 | 6.77 |
| CHEMBL5087418 | — | — | 1 | 6.77 |
| CHEMBL5076358 | — | — | 1 | 6.58 |
| CHEMBL5089586 | — | — | 1 | 6.57 |
| CHEMBL5078991 | — | — | 1 | 6.54 |
| CHEMBL5077047 | — | — | 1 | 6.42 |
| CHEMBL5083939 | — | — | 1 | 6.35 |
| CHEMBL4777742 | — | — | 1 | 6.35 |
| CHEMBL5089485 | — | — | 1 | 6.33 |
| CHEMBL5094515 | — | — | 1 | 6.28 |
| CHEMBL5091586 | — | — | 1 | 6.24 |
| CHEMBL5093590 | — | — | 1 | 6.12 |
| CHEMBL5077670 | — | — | 1 | 5.89 |
| CHEMBL5091037 | — | — | 1 | 5.80 |
| CHEMBL5077619 | — | — | 1 | 5.72 |
| CHEMBL5072498 | — | — | 1 | 5.66 |
| CHEMBL5081962 | — | — | 1 | 5.64 |
| CHEMBL5092257 | — | — | 1 | 5.55 |
| CHEMBL5078924 | — | — | 1 | 5.15 |
| CHEMBL5084334 | — | — | 1 | - |
| CHEMBL5076480 | — | — | 1 | - |
| CHEMBL5092648 | — | — | 1 | - |
| CHEMBL5072526 | — | — | 1 | - |
| CHEMBL5076866 | — | — | 1 | - |
| CHEMBL5078497 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4094088 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL5073339 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL4740928 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4066553 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5085151 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5077758 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5087418 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5076358 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5089586 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5078991 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5077047 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL5083939 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4777742 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL5089485 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL5094515 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL5091586 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL5093590 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL5077670 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5091037 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5077619 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5072498 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5081962 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5092257 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL5078924 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL5080663 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL5071689 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL5090806 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL5092163 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL5076723 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL5078497 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL5076866 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL5072526 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL5092648 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL5076480 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL5084334 | — | IC50 | > | 64000.0 | nM | - |