Assay Detail
Binding
CHEMBL5036493
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant HDAC6 (unknown origin) using Boc-Lys(acetyl)-AMC as substrate preincubated for 1 hr followed by substrate addition and measured after 2 hrs by fluorescence based assay
23
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Melatonin- and Ferulic Acid-Based HDAC6 Selective Inhibitors Exhibit Pronounced Immunomodulatory Effects <i>In Vitro</i> and Neuroprotective Effects in a Pharmacological Alzheimer's Disease Mouse Model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.43 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2364628 | RICOLINOSTAT | 2.0 | 1 | 8.33 |
| CHEMBL5076794 | — | — | 2 | 7.95 |
| CHEMBL5090786 | — | — | 2 | 7.72 |
| CHEMBL141502 | — | — | 2 | 7.67 |
| CHEMBL5080111 | — | — | 2 | 7.59 |
| CHEMBL5072502 | — | — | 2 | 7.51 |
| CHEMBL5070312 | — | — | 2 | 7.47 |
| CHEMBL5081920 | — | — | 2 | 7.28 |
| CHEMBL5092272 | — | — | 2 | 7.27 |
| CHEMBL5092694 | — | — | 2 | 7.24 |
| CHEMBL5078976 | — | — | 2 | 7.16 |
| CHEMBL5087002 | — | — | 2 | 6.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2364628 | RICOLINOSTAT | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL5076794 | — | IC50 | = | 11.2 | nM | 7.95 |
| CHEMBL5076794 | — | IC50 | = | 11.22 | nM | 7.95 |
| CHEMBL5090786 | — | IC50 | = | 19.1 | nM | 7.72 |
| CHEMBL5090786 | — | IC50 | = | 19.05 | nM | 7.72 |
| CHEMBL141502 | — | IC50 | = | 21.4 | nM | 7.67 |
| CHEMBL141502 | — | IC50 | = | 21.38 | nM | 7.67 |
| CHEMBL5080111 | — | IC50 | = | 25.7 | nM | 7.59 |
| CHEMBL5080111 | — | IC50 | = | 25.6 | nM | 7.59 |
| CHEMBL5072502 | — | IC50 | = | 30.9 | nM | 7.51 |
| CHEMBL5072502 | — | IC50 | = | 30.7 | nM | 7.51 |
| CHEMBL5070312 | — | IC50 | = | 33.7 | nM | 7.47 |
| CHEMBL5070312 | — | IC50 | = | 33.88 | nM | 7.47 |
| CHEMBL5081920 | — | IC50 | = | 52.3 | nM | 7.28 |
| CHEMBL5081920 | — | IC50 | = | 52.48 | nM | 7.28 |
| CHEMBL5092272 | — | IC50 | = | 53.2 | nM | 7.27 |
| CHEMBL5092272 | — | IC50 | = | 53.7 | nM | 7.27 |
| CHEMBL5092694 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL5092694 | — | IC50 | = | 57.54 | nM | 7.24 |
| CHEMBL5078976 | — | IC50 | = | 69.18 | nM | 7.16 |
| CHEMBL5078976 | — | IC50 | = | 68.8 | nM | 7.16 |
| CHEMBL5087002 | — | IC50 | = | 353.0 | nM | 6.45 |
| CHEMBL5087002 | — | IC50 | = | 354.81 | nM | 6.45 |