Assay Detail
Binding
CHEMBL5036497
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant HDAC1 (unknown origin) using Boc-Lys(Ac)-AMC as substrate pre-incubated for 1 hr followed by substrate addition and measured after 2 hrs by fluorescence based assay
4
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Melatonin- and Ferulic Acid-Based HDAC6 Selective Inhibitors Exhibit Pronounced Immunomodulatory Effects <i>In Vitro</i> and Neuroprotective Effects in a Pharmacological Alzheimer's Disease Mouse Model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.35 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5076794 | — | — | 2 | 6.58 |
| CHEMBL5072502 | — | — | 2 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5076794 | — | IC50 | = | 262.0 | nM | 6.58 |
| CHEMBL5076794 | — | IC50 | = | 263.03 | nM | 6.58 |
| CHEMBL5072502 | — | IC50 | = | 771.0 | nM | 6.11 |
| CHEMBL5072502 | — | IC50 | = | 776.25 | nM | 6.11 |