Assay Detail
Binding
CHEMBL5036668
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Inhibition of human recombinant sEH using CMNPC as substrate incubated for 5 mins by fluorescent based assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
From the Design to the <i>In Vivo</i> Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase Inhibitors for the Treatment of Acute Pancreatitis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 8.22 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5084744 | — | — | 1 | 9.40 |
| CHEMBL4752759 | — | — | 1 | 9.40 |
| CHEMBL5093683 | — | — | 1 | 9.30 |
| CHEMBL242459 | — | — | 1 | 9.30 |
| CHEMBL5081862 | — | — | 1 | 9.05 |
| CHEMBL5080024 | — | — | 1 | 9.00 |
| CHEMBL5081815 | — | — | 1 | 8.51 |
| CHEMBL1818385 | — | — | 1 | 8.11 |
| CHEMBL436774 | AR9281 | 2.0 | 1 | 8.10 |
| CHEMBL4779073 | — | — | 1 | 8.05 |
| CHEMBL5083623 | — | — | 1 | 7.70 |
| CHEMBL4797443 | — | — | 1 | 7.67 |
| CHEMBL5084924 | — | — | 1 | 7.55 |
| CHEMBL4759592 | — | — | 1 | 7.52 |
| CHEMBL5090478 | — | — | 1 | 6.86 |
| CHEMBL5083763 | — | — | 1 | 6.03 |
| CHEMBL5094924 | — | — | 1 | - |
| CHEMBL5083283 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5084744 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4752759 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5093683 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL242459 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL5081862 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL5080024 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5081815 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL1818385 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL436774 | AR9281 | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4779073 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5083623 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4797443 | — | IC50 | = | 21.3 | nM | 7.67 |
| CHEMBL5084924 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4759592 | — | IC50 | = | 29.9 | nM | 7.52 |
| CHEMBL5090478 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL5083763 | — | IC50 | = | 941.0 | nM | 6.03 |
| CHEMBL5094924 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5083283 | — | IC50 | > | 10000.0 | nM | - |