Assay Detail
Binding
CHEMBL5036837
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of wild-type human STING expressed in digitonin treated HEK293T cells co-expressing IRF3-activated ISRE assessed as IRF3 reporter activation by luciferase reporter gene assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Stimulator of interferon genes protein (CHEMBL4523377) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3',3'-c-Di(2'F,2'dAMP).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 7.20 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5078036 | — | — | 1 | 8.15 |
| CHEMBL5093813 | — | — | 1 | 7.70 |
| CHEMBL5090007 | — | — | 1 | 7.70 |
| CHEMBL4577528 | — | — | 1 | 7.70 |
| CHEMBL4435159 | — | — | 1 | 7.52 |
| CHEMBL5076132 | — | — | 1 | 7.40 |
| CHEMBL5071466 | — | — | 1 | 7.40 |
| CHEMBL4449584 | — | — | 1 | 6.92 |
| CHEMBL5082153 | — | — | 1 | 6.77 |
| CHEMBL1229884 | — | — | 1 | 6.58 |
| CHEMBL1231573 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5078036 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5093813 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5090007 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4577528 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4435159 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5076132 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5071466 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4449584 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5082153 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1229884 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1231573 | — | EC50 | = | 4470.0 | nM | 5.35 |