Assay Detail
Binding
CHEMBL5036839
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Activation of human STING REF mutant expressed in digitonin treated HEK293T cells co-expressing IRF3-activated ISRE assessed as IRF3 reporter activation by luciferase reporter gene assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3',3'-c-Di(2'F,2'dAMP).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 6.23 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4577528 | — | — | 1 | 7.16 |
| CHEMBL5076132 | — | — | 1 | 6.89 |
| CHEMBL5071466 | — | — | 1 | 6.85 |
| CHEMBL5093813 | — | — | 1 | 6.75 |
| CHEMBL4435159 | — | — | 1 | 6.68 |
| CHEMBL5090007 | — | — | 1 | 6.44 |
| CHEMBL5078036 | — | — | 1 | 6.04 |
| CHEMBL4449584 | — | — | 1 | 5.37 |
| CHEMBL1231573 | — | — | 1 | 5.08 |
| CHEMBL5082153 | — | — | 1 | 5.06 |
| CHEMBL1229884 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4577528 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5076132 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5071466 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5093813 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4435159 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5090007 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5078036 | — | EC50 | = | 920.0 | nM | 6.04 |
| CHEMBL4449584 | — | EC50 | = | 4260.0 | nM | 5.37 |
| CHEMBL1231573 | — | EC50 | = | 8410.0 | nM | 5.08 |
| CHEMBL5082153 | — | EC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL1229884 | — | EC50 | > | 45000.0 | nM | - |