Assay Detail
Binding
CHEMBL5036840
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of human STING QA mutant expressed in digitonin treated HEK293T cells co-expressing IRF3-activated ISRE assessed as IRF3 reporter activation by luciferase reporter gene assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Stimulator of interferon genes protein (CHEMBL4523377) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3',3'-c-Di(2'F,2'dAMP).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 7.06 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5090007 | — | — | 1 | 7.52 |
| CHEMBL4435159 | — | — | 1 | 7.52 |
| CHEMBL5076132 | — | — | 1 | 7.40 |
| CHEMBL5071466 | — | — | 1 | 7.40 |
| CHEMBL4577528 | — | — | 1 | 7.40 |
| CHEMBL5093813 | — | — | 1 | 7.30 |
| CHEMBL5078036 | — | — | 1 | 7.16 |
| CHEMBL1229884 | — | — | 1 | 6.77 |
| CHEMBL5082153 | — | — | 1 | 6.58 |
| CHEMBL4449584 | — | — | 1 | 6.58 |
| CHEMBL1231573 | — | — | 1 | 5.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5090007 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4435159 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5076132 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5071466 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4577528 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5093813 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5078036 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1229884 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5082153 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4449584 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1231573 | — | EC50 | = | 1050.0 | nM | 5.98 |