Assay Detail
Binding
CHEMBL5036844
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Activation of wild-type human STING expressed in HEK293T cells co-expressing IRF3-activated ISRE assessed as IRF3 reporter activation measured after 7 hrs by luciferase reporter gene assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Stimulator of interferon genes protein (CHEMBL4523377) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3',3'-c-Di(2'F,2'dAMP).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 6.73 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5075359 | — | — | 1 | 8.00 |
| CHEMBL5073386 | — | — | 1 | 7.70 |
| CHEMBL5079226 | — | — | 1 | 7.52 |
| CHEMBL5080355 | — | — | 1 | 7.52 |
| CHEMBL5079224 | — | — | 1 | 7.40 |
| CHEMBL5089205 | — | — | 1 | 7.40 |
| CHEMBL5078789 | — | — | 1 | 7.40 |
| CHEMBL5076372 | — | — | 1 | 7.16 |
| CHEMBL5074770 | — | — | 1 | 6.92 |
| CHEMBL5093084 | — | — | 1 | 6.89 |
| CHEMBL5093147 | — | — | 1 | 6.77 |
| CHEMBL5080867 | — | — | 1 | 6.50 |
| CHEMBL5083793 | — | — | 1 | 6.40 |
| CHEMBL5089851 | — | — | 1 | 6.35 |
| CHEMBL5093813 | — | — | 1 | 5.10 |
| CHEMBL4435159 | — | — | 1 | 4.93 |
| CHEMBL4577528 | — | — | 1 | 4.42 |
| CHEMBL4449584 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5075359 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5073386 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5079226 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5080355 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5079224 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5089205 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5078789 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5076372 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5074770 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5093084 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5093147 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5080867 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL5083793 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5089851 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL5093813 | — | EC50 | = | 7990.0 | nM | 5.10 |
| CHEMBL4435159 | — | EC50 | = | 11680.0 | nM | 4.93 |
| CHEMBL4577528 | — | EC50 | = | 37560.0 | nM | 4.42 |
| CHEMBL4449584 | — | EC50 | = | 100700.0 | nM | - |