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Assay Detail

CHEMBL5036849

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Induction of INF-alpha production in healthy human PBMC incubated for 16 hrs
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type PBMC
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3',3'-c-Di(2'F,2'dAMP).
Pimková Polidarová M, Břehová P, Kaiser MM, Smola M, Dračínský M, Smith J, Marek A, Dejmek M, Šála M, Gutten O, Rulíšek L, Novotná B, Brázdová A, Janeba Z, Nencka R, Boura E, Páv O, Birkuš G.
J Med Chem (2021) 64 : 7596 -7616
PubMed 34019405 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 17 5.70 7.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5075359 1 7.30
CHEMBL5079224 1 7.16
CHEMBL5074770 1 6.89
CHEMBL5073386 1 6.66
CHEMBL5080355 1 6.58
CHEMBL5079226 1 6.44
CHEMBL5078789 1 6.36
CHEMBL5089205 1 6.16
CHEMBL5076372 1 6.14
CHEMBL5093147 1 5.89
CHEMBL4435159 1 4.76
CHEMBL5090007 1 4.75
CHEMBL4449584 1 4.57
CHEMBL5082153 1 4.53
CHEMBL5076132 1 4.41
CHEMBL5093813 1 4.29
CHEMBL4577528 1 4.03

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5075359 EC50 = 50.0 nM 7.30
CHEMBL5079224 EC50 = 70.0 nM 7.16
CHEMBL5074770 EC50 = 130.0 nM 6.89
CHEMBL5073386 EC50 = 220.0 nM 6.66
CHEMBL5080355 EC50 = 260.0 nM 6.58
CHEMBL5079226 EC50 = 360.0 nM 6.44
CHEMBL5078789 EC50 = 440.0 nM 6.36
CHEMBL5089205 EC50 = 700.0 nM 6.16
CHEMBL5076372 EC50 = 720.0 nM 6.14
CHEMBL5093147 EC50 = 1290.0 nM 5.89
CHEMBL4435159 EC50 = 17300.0 nM 4.76
CHEMBL5090007 EC50 = 17710.0 nM 4.75
CHEMBL4449584 EC50 = 26710.0 nM 4.57
CHEMBL5082153 EC50 = 29590.0 nM 4.53
CHEMBL5076132 EC50 = 38660.0 nM 4.41
CHEMBL5093813 EC50 = 50960.0 nM 4.29
CHEMBL4577528 EC50 = 92930.0 nM 4.03