Assay Detail
Functional
CHEMBL5036853
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Induction of TNF-alpha production in healthy human PBMC incubated for 16 hrs
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3',3'-c-Di(2'F,2'dAMP).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 6.15 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5075359 | — | — | 1 | 7.70 |
| CHEMBL5080355 | — | — | 1 | 7.16 |
| CHEMBL5074770 | — | — | 1 | 7.00 |
| CHEMBL5079224 | — | — | 1 | 7.00 |
| CHEMBL5073386 | — | — | 1 | 6.96 |
| CHEMBL5076372 | — | — | 1 | 6.75 |
| CHEMBL5089205 | — | — | 1 | 6.64 |
| CHEMBL5078789 | — | — | 1 | 6.62 |
| CHEMBL5079226 | — | — | 1 | 6.46 |
| CHEMBL5093147 | — | — | 1 | 6.15 |
| CHEMBL5090007 | — | — | 1 | 5.14 |
| CHEMBL5076132 | — | — | 1 | 5.03 |
| CHEMBL5093813 | — | — | 1 | 4.89 |
| CHEMBL5082153 | — | — | 1 | 4.57 |
| CHEMBL4435159 | — | — | 1 | 4.14 |
| CHEMBL4577528 | — | — | 1 | - |
| CHEMBL4449584 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5075359 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5080355 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5074770 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5079224 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5073386 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5076372 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5089205 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5078789 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5079226 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL5093147 | — | EC50 | = | 710.0 | nM | 6.15 |
| CHEMBL5090007 | — | EC50 | = | 7290.0 | nM | 5.14 |
| CHEMBL5076132 | — | EC50 | = | 9370.0 | nM | 5.03 |
| CHEMBL5093813 | — | EC50 | = | 12780.0 | nM | 4.89 |
| CHEMBL5082153 | — | EC50 | = | 26820.0 | nM | 4.57 |
| CHEMBL4435159 | — | EC50 | = | 72630.0 | nM | 4.14 |
| CHEMBL4577528 | — | EC50 | = | 216300.0 | nM | - |
| CHEMBL4449584 | — | EC50 | > | 300000.0 | nM | - |