Assay Detail
Functional
CHEMBL5036866
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Cytotoxicity against human MOLT-4 cells assessed as reduction in cell viability measured after 24 hrs by CCK-8 assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLT-4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel Benzothiazepinones as Irreversible Covalent Glycogen Synthase Kinase 3β Inhibitors for the Treatment of Acute Promyelocytic Leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.09 | 4.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5091900 | — | — | 1 | 4.19 |
| CHEMBL5071369 | — | — | 1 | 4.12 |
| CHEMBL5089457 | — | — | 1 | 4.12 |
| CHEMBL5092483 | — | — | 1 | 4.11 |
| CHEMBL5073147 | — | — | 1 | 4.10 |
| CHEMBL5083185 | — | — | 1 | 4.09 |
| CHEMBL5088760 | — | — | 1 | 4.08 |
| CHEMBL5091334 | — | — | 1 | 4.08 |
| CHEMBL5086342 | — | — | 1 | 4.07 |
| CHEMBL5079142 | — | — | 1 | 4.07 |
| CHEMBL5083742 | — | — | 1 | 4.06 |
| CHEMBL5092006 | — | — | 1 | 4.05 |
| CHEMBL5091647 | — | — | 1 | 4.04 |
| CHEMBL5084565 | — | — | 1 | 4.01 |
| CHEMBL5089459 | — | — | 1 | - |
| CHEMBL5085162 | — | — | 1 | - |
| CHEMBL5091798 | — | — | 1 | - |
| CHEMBL5083481 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5091900 | — | IC50 | = | 65030.0 | nM | 4.19 |
| CHEMBL5071369 | — | IC50 | = | 75580.0 | nM | 4.12 |
| CHEMBL5089457 | — | IC50 | = | 76310.0 | nM | 4.12 |
| CHEMBL5092483 | — | IC50 | = | 77520.0 | nM | 4.11 |
| CHEMBL5073147 | — | IC50 | = | 79640.0 | nM | 4.10 |
| CHEMBL5083185 | — | IC50 | = | 80270.0 | nM | 4.09 |
| CHEMBL5088760 | — | IC50 | = | 82360.0 | nM | 4.08 |
| CHEMBL5091334 | — | IC50 | = | 83160.0 | nM | 4.08 |
| CHEMBL5086342 | — | IC50 | = | 84430.0 | nM | 4.07 |
| CHEMBL5079142 | — | IC50 | = | 85920.0 | nM | 4.07 |
| CHEMBL5083742 | — | IC50 | = | 87610.0 | nM | 4.06 |
| CHEMBL5092006 | — | IC50 | = | 88720.0 | nM | 4.05 |
| CHEMBL5091647 | — | IC50 | = | 91500.0 | nM | 4.04 |
| CHEMBL5084565 | — | IC50 | = | 97540.0 | nM | 4.01 |
| CHEMBL5089459 | — | IC50 | = | 106350.0 | nM | - |
| CHEMBL5085162 | — | IC50 | = | 556720.0 | nM | - |
| CHEMBL5091798 | — | IC50 | = | 565400.0 | nM | - |
| CHEMBL5083481 | — | IC50 | = | 729840.0 | nM | - |