Assay Detail
Functional
CHEMBL5037039
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Antiproliferative activity against human HD-MB03 cells assessed as reduction in cell viability measured after 3 days by CellTiter-Glo assay
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HD-MB03 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 5.45 | 5.45 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5094191 | — | — | 1 | 5.45 |
| CHEMBL5084741 | — | — | 1 | - |
| CHEMBL4170596 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5094191 | — | EC50 | = | 3583.0 | nM | 5.45 |
| CHEMBL5084741 | — | EC50 | > | 8.0 | nM | - |
| CHEMBL4170596 | — | Activity | - | — | - |