Assay Detail
Binding
CHEMBL5037110
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Agonist activity at human TLR7 expressed in HEK293 cells incubated for 6 to 16 hrs by SEAP reporter gene assay
65
Total Activities
65
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Design of Highly Potent Toll-like Receptor 7/8 Dual Agonists for Cancer Immunotherapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 65 | 6.23 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5090317 | — | — | 1 | 7.70 |
| CHEMBL5077799 | — | — | 1 | 7.62 |
| CHEMBL5079043 | — | — | 1 | 7.57 |
| CHEMBL5094792 | — | — | 1 | 7.55 |
| CHEMBL5083795 | — | — | 1 | 7.48 |
| CHEMBL5085705 | — | — | 1 | 7.40 |
| CHEMBL5079288 | — | — | 1 | 7.33 |
| CHEMBL5087987 | — | — | 1 | 7.30 |
| CHEMBL5083597 | — | — | 1 | 7.24 |
| CHEMBL5079616 | — | — | 1 | 7.18 |
| CHEMBL5076212 | — | — | 1 | 7.16 |
| CHEMBL5071236 | — | — | 1 | 7.15 |
| CHEMBL383322 | RESIQUIMOD | 2.0 | 1 | 7.12 |
| CHEMBL5073114 | — | — | 1 | 7.10 |
| CHEMBL5088082 | — | — | 1 | 7.02 |
| CHEMBL5091330 | — | — | 1 | 6.96 |
| CHEMBL5080899 | — | — | 1 | 6.87 |
| CHEMBL5073954 | — | — | 1 | 6.81 |
| CHEMBL5090751 | — | — | 1 | 6.81 |
| CHEMBL5080244 | — | — | 1 | 6.52 |
| CHEMBL5091071 | — | — | 1 | 6.52 |
| CHEMBL5090854 | — | — | 1 | 6.40 |
| CHEMBL5093105 | — | — | 1 | 6.20 |
| CHEMBL5082702 | — | — | 1 | 6.12 |
| CHEMBL5094134 | — | — | 1 | 6.10 |
| CHEMBL5083582 | — | — | 1 | 6.05 |
| CHEMBL5082334 | — | — | 1 | 5.95 |
| CHEMBL5082922 | — | — | 1 | 5.93 |
| CHEMBL5088598 | — | — | 1 | 5.93 |
| CHEMBL5080154 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5090317 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5077799 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5079043 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5094792 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5083795 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL5085705 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5079288 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL5087987 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5083597 | — | EC50 | = | 58.0 | nM | 7.24 |
| CHEMBL5079616 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL5076212 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5071236 | — | EC50 | = | 71.0 | nM | 7.15 |
| CHEMBL383322 | RESIQUIMOD | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL5073114 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5088082 | — | EC50 | = | 95.0 | nM | 7.02 |
| CHEMBL5091330 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5080899 | — | EC50 | = | 136.0 | nM | 6.87 |
| CHEMBL5073954 | — | EC50 | = | 156.0 | nM | 6.81 |
| CHEMBL5090751 | — | EC50 | = | 156.0 | nM | 6.81 |
| CHEMBL5080244 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5091071 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5090854 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5093105 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL5082702 | — | EC50 | = | 760.0 | nM | 6.12 |
| CHEMBL5094134 | — | EC50 | = | 795.0 | nM | 6.10 |
| CHEMBL5083582 | — | EC50 | = | 890.0 | nM | 6.05 |
| CHEMBL5082334 | — | EC50 | = | 1122.0 | nM | 5.95 |
| CHEMBL5082922 | — | EC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL5088598 | — | EC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL5080154 | — | EC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL5092548 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5094238 | — | EC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL5072172 | — | EC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL5079679 | — | EC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL5093929 | — | EC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL5081740 | — | EC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL5083214 | — | EC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL5077793 | — | EC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL5083102 | — | EC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL5081963 | — | EC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL5094002 | — | EC50 | = | 1835.0 | nM | 5.74 |
| CHEMBL5079942 | — | EC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL5086782 | — | EC50 | = | 2152.0 | nM | 5.67 |
| CHEMBL5070913 | — | EC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL5091725 | — | EC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL5084664 | — | EC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL5078911 | — | EC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL5078201 | — | EC50 | = | 3950.0 | nM | 5.40 |
| CHEMBL5080312 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL5076862 | — | EC50 | = | 5000.0 | nM | 5.30 |