Assay Detail
Functional
CHEMBL5037523
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Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by cell counter method
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Balanced dual acting compounds targeting aromatase and estrogen receptor α as an emerging therapeutic opportunity to counteract estrogen responsive breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.72 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1093458 | ENDOXIFEN | 3.0 | 1 | 7.00 |
| CHEMBL1444 | LETROZOLE | 4.0 | 1 | 5.39 |
| CHEMBL5082245 | — | — | 1 | 5.00 |
| CHEMBL5072101 | — | — | 1 | 4.61 |
| CHEMBL5080066 | — | — | 1 | 4.56 |
| CHEMBL5087363 | — | — | 1 | 4.43 |
| CHEMBL5074047 | — | — | 1 | 4.43 |
| CHEMBL5081446 | — | — | 1 | 4.40 |
| CHEMBL5069811 | — | — | 1 | 4.38 |
| CHEMBL5092560 | — | — | 1 | 4.38 |
| CHEMBL5077976 | — | — | 1 | 4.28 |
| CHEMBL5082681 | — | — | 1 | 4.24 |
| CHEMBL5075144 | — | — | 1 | 4.22 |
| CHEMBL5092843 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1093458 | ENDOXIFEN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1444 | LETROZOLE | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5082245 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5072101 | — | IC50 | = | 24300.0 | nM | 4.61 |
| CHEMBL5080066 | — | IC50 | = | 27600.0 | nM | 4.56 |
| CHEMBL5087363 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL5074047 | — | IC50 | = | 37100.0 | nM | 4.43 |
| CHEMBL5081446 | — | IC50 | = | 39800.0 | nM | 4.40 |
| CHEMBL5069811 | — | IC50 | = | 41200.0 | nM | 4.38 |
| CHEMBL5092560 | — | IC50 | = | 42100.0 | nM | 4.38 |
| CHEMBL5077976 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL5082681 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL5075144 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL5092843 | — | IC50 | > | 100000.0 | nM | - |