Assay Detail
Functional
CHEMBL5037524
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Antiproliferative activity against human MCF-10A cells assessed as reduction in cell viability after 72 hrs by cell counter method
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF-10A |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Balanced dual acting compounds targeting aromatase and estrogen receptor α as an emerging therapeutic opportunity to counteract estrogen responsive breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.45 | 4.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5082245 | — | — | 1 | 4.77 |
| CHEMBL5092560 | — | — | 1 | 4.70 |
| CHEMBL5072101 | — | — | 1 | 4.46 |
| CHEMBL5077976 | — | — | 1 | 4.38 |
| CHEMBL5081446 | — | — | 1 | 4.30 |
| CHEMBL5087363 | — | — | 1 | 4.28 |
| CHEMBL5069811 | — | — | 1 | 4.23 |
| CHEMBL5075144 | — | — | 1 | - |
| CHEMBL5082681 | — | — | 1 | - |
| CHEMBL5080066 | — | — | 1 | - |
| CHEMBL5092843 | — | — | 1 | - |
| CHEMBL5074047 | — | — | 1 | - |
| CHEMBL1093458 | ENDOXIFEN | 3.0 | 1 | - |
| CHEMBL1444 | LETROZOLE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5082245 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL5092560 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5072101 | — | IC50 | = | 34700.0 | nM | 4.46 |
| CHEMBL5077976 | — | IC50 | = | 41700.0 | nM | 4.38 |
| CHEMBL5081446 | — | IC50 | = | 50400.0 | nM | 4.30 |
| CHEMBL5087363 | — | IC50 | = | 52500.0 | nM | 4.28 |
| CHEMBL5069811 | — | IC50 | = | 58700.0 | nM | 4.23 |
| CHEMBL5075144 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5082681 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5080066 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5092843 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5074047 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1093458 | ENDOXIFEN | IC50 | > | 10000.0 | nM | - |
| CHEMBL1444 | LETROZOLE | IC50 | > | 10000.0 | nM | - |