Assay Detail
Binding
CHEMBL5037536
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Modulator activity at human Nav1.7 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-electrode voltage clamp assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Oocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium channel protein type 9 subunit alpha (CHEMBL4296) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Functional Characterization of the Nemertide α Family of Peptide Toxins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.88 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5093878 | — | — | 1 | 7.14 |
| CHEMBL5091679 | — | — | 1 | 7.12 |
| CHEMBL5077579 | — | — | 1 | 7.09 |
| CHEMBL5082582 | — | — | 1 | 7.01 |
| CHEMBL5091623 | — | — | 1 | 6.99 |
| CHEMBL5084333 | — | — | 1 | 6.89 |
| CHEMBL5083412 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5093878 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL5091679 | — | EC50 | = | 76.5 | nM | 7.12 |
| CHEMBL5077579 | — | EC50 | = | 80.5 | nM | 7.09 |
| CHEMBL5082582 | — | EC50 | = | 97.2 | nM | 7.01 |
| CHEMBL5091623 | — | EC50 | = | 102.2 | nM | 6.99 |
| CHEMBL5084333 | — | EC50 | = | 129.0 | nM | 6.89 |
| CHEMBL5083412 | — | EC50 | = | 1296.7 | nM | 5.89 |